6ème Journées du Réseau "France Microtubules"

9:15 - 10:30 (1h15)

Microtubule assembly

amphitheatre CBI 0028

› Beyond mitosis: targeted degradation uncovers novel interphase functions of augmin. - Marcos Fariña-Mosquera, Institute for Research in Biomedicine [Barcelona, Spain] 09:15-09:30 (15min)

› C- and D-type lateral interactions weaken the microtubule lattice - Matthieu Benoit, Institut de Génétique et Développement de Rennes (IGDR) UMR 6290, MiToS team 09:30-09:45 (15min)

› Mechanistic Dissection of γTuRC Activation by Centrosomin Motif 1 (CM1) - Cláudia Fernandes Brito, Centro de Regulación Genómica 09:45-10:00 (15min)

› Xenopus spermatid microtubules contain an internal helix - Céline Callens, Institut de Génétique et Développement de Rennes 10:00-10:15 (15min)

› Stable GDP-tubulin islands rescue dynamic microtubules - Virginie Stoppin-Mellet, Grenoble Institut des Neurosciences 10:15-10:30 (15min)

10:30 - 11:00 (30min)

Coffee break

CBI entrance

11:00 - 12:00 (1h)

Microtubule-dependent motors and transport

amphitheatre CBI 0028

› Precise control of microtubule structure and intracellular trafficking in living cells and behaving animals - Yu-Chun Lin, National Tsing Hua University [Hsinchu] 11:00-11:15 (15min)

› Spatial activation of Kinesin-1 by Ensconsin shapes microtubule networks via ncMTOCs recruitment - Laetitia Bataillé, Institut de Génétique et Développement de Rennes (IGDR), Univ Rennes, CNRS, UMR 6290, INSERM ERL U1305 11:15-11:30 (15min)

› NuMA is a mitotic adaptor protein that activates dynein and connects it to microtubule minus ends - Sabina Colombo, Centro de Regulación Genómica (CRG) 11:30-11:45 (15min)

› Kinesin-12 KLP-18 contributes to the kinetochore-microtubule poleward flux during the metaphase of C. elegans one-cell embryo. - Mathis Da Silva, Institut de Génétique et Développement de Rennes 11:45-12:00 (15min)

12:00 - 14:00 (2h)

Lunch

14:00 - 14:45 (45min)

Microtubule inhibitors

amphitheatre CBI 0028

› A new nanoDSF approach to anti-tubulin compounds screening - Philipp TSVETKOV, Institut de neurophysiopathologie 14:00-14:15 (15min)

› Effects of oxfendazole, a microtubule-targeting agent, on the development of filarial parasites - Linda KOHL, UMR7245 MCAM, MNHN-CNRS 14:15-14:30 (15min)

› Peptide-based covalent inhibitor of tubulin detyrosination promotes mesenchymal-to-epithelial transition in lung cancer cells - Ghislain Gillard, Institut de Génétique Humaine 14:30-14:45 (15min)

14:45 - 15:30 (45min)

prizes for junior presenters, planning of future meetings, closing remarks

amphitheatre CBI 0028